Just doing some research, figured I should post it as I go.
Yohimbe, and its subset yohimbine, are fat-burning compounds, primarily used to lose fat during short term fasting.
Yohimbine is also an aphrodisiac and can aid erectile dysfunction. It is also a general stimulant.
Yohimbine works by increasing adrenaline levels in the body, as well as inhibiting a regulatory process in fat cells, which normally suppresses fat burning.
The effects of yohimbine are partially negated by food intake, which is why it is often taken in a fasted state.
Also Known As
Yohimbe, Corynanthe Yohimbe, Yohimbe Bark
Things to Note
Yohimbe is highly stimulatory
There is a high chance of yohimbine interacting with neurological medication
Caution Notice
Yohimbine can cause extreme anxiety in individuals predisposed to anxiety. Yohimbine may trigger manic psychosis or suicidal episodes in people with bipolar disorder.
Yohimbine can interact with a large amount of neurological medications and should not be used in conjunction with these medication without consultation with a doctor
How to Take (recommended dosage, active amounts, other details)
Dosages of 0.2mg/kg bodyweight have been successfully used to increase fat burning without significant implications on cardiovascular parameters like heart rate and blood pressure. This results in a dosage of: Work up to these dosages!
14 mg for a 150lb person
18 mg for a 200lb person
22 mg for a 250lb person
Supplementation is most effective between meals or during short term fasting.
Caution should be exercised at higher body weight, since the cardiovascular system may not be prepared to handle a stimulatory agent such as yohimbine. When supplementing yohimbine for the first time, always start with a half-dose and assess tolerance before proceeding.
When pairing yohimbine with other stimulatory agents, half-dose both supplements and work up to the recommended dose cautiously, as two supplements can interact negatively.
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what effect Yohimbine has in your body, and how strong these effects are.
A) Robust research conducted with repeated double blind clinical trials
B) Multiple studies where at least two are double-blind and placebo controlled
C) Single double blind study or multiple cohort studies
D) Uncontrolled or observational studies only
B) Erections, Minor Effect
Erections are increased following yohimbine ingestion which is thought to be a combination of alpha-2-adrenergic antagonism (enhancing relaxation of the penile tissue so engorgement of blood can ensure) and increasing blood pressure (which would increase the amount of force in an erection). However, may not be able to overcome organic erectile dysfunction associated with poor blood flow
C) Symptoms of Phobia, Minor Effect
Thought to decrease symptoms of phobia via noradrenaline release (causing densensitization to the stress response) but studies looking at its efficacy are mixed.
C) Cortisol, Minor
Appears to increase cortisol following ingestion
C) Anxiety, Minor
Although unreliable, an increase in anxiety may occur following yohimbine ingestion
C) Heart Rate, Minor
Due to stimulatory effects, an increase in heart rate follows yohimbine ingestion
C) Blood Pressure, Minor
Appears to increase blood pressure, which may aid the proerectile effects (as it is an acute increase) but is a cardiovascular risk factor
C) Lean Mass
No significant influence on lean mass detected with yohimbine ingestion
C) Fat Mass, Notable
Fat mass is reduced with yohimbine ingestion and appears to affect both obese and lean individuals
C) Power Output
No significant influence on power output noted with yohimbine
C) Alcohol Dependence, Minor
Injections of yohimbine have been noted to increase cravings for alcohol, which although not demonstrated with oral intake is thought to be related to the reduction in inhibition
C) Rate of Gastric Emptying
No significant effect on gastric emptying rate
C) Diuresis, Minor
There appears to be an increased urge to urinate following supplementation of yohimbine
C Plasma Melatonin
Despite increased rates of melatonin elimination from the body (via urinartion), there does not appear to be a significant influence on plasma melatonin concentrations.
D) Symptoms of Orthostatic Hypotension
Orthostatic hypotension (light headedness upon rapidly standing up) appears to have reduced symptoms associated with yohimbine usage
D) Cerebral Blood Flow, Minor
A decrease in cerebral blood flow has been noted to be independent of cognitive impairment
D) Testosterone
No significant influence on testosterone seen with yohimbine supplementation
D) Penile Girth lol, Minor
An increase in penile girth has been noted (similar to L-DOPA) which was not to a large degree, only detectable when dividing the group into responders and nonresponders