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Thread: Potentially harmful filler in supps and meds

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    Senior Member baby1's Avatar
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    Potentially harmful filler in supps and meds

    Is magnesium stearate safe to use as a supplement excipient?

    There is much debate among supplement manufacturers, practitioners and the general public on the use of magnesium stearate and other excipients. Many say that it is not toxic and fine for use in foods and food supplements, while others say the opposite.
    We firmly believe that excipients such as magnesium stearate should not be in food supplements due to toxicity and reduced bioavailability. Please don't just accept this, take a look for yourself . . . but before you do lets take a scientific look at precisely what magnesium stearate is.

    What is magnesium stearate?

    Magnesium stearate is a lubricant, a salt containing two equivalents of stearate (the negatively charged anion of stearic acid) and one positively charged magnesium cation (Mg2+). Magnesium stearate is also called octadecanoic acid and magnesium salt. Magnesium stearate is not soluble in water and has hydrophobic properties, meaning that it is water-repelling. Its chemical formula is Mg(C18H35O2)2 and it is a very fine white powder with a soapy texture.

    What is magnesium stearate used for?

    The main use of magnesium stearate is in the manufacture of tablet, capsule and powder supplements. It is added to formulations to improve the flow properties of the powder, this also helps to compress the tablet without sticking to the mold and machinery parts whilst improving clean down time. Magnesium stearate is typically used in a concentration range of 0.25% to 2% but we have heard of it being used up to 5%. High values can result in decreased absorption of the product; in the pharma industry it is widely known that magnesium stearate prolongs disintegration.

    What is magnesium stearate derived from?

    Magnesium stearate is made from bovine and vegetable sources. The vegetable source is made by hydrogenating cottonseed or palm oil. Cotton crops are heavily sprayed and have the highest content of pesticide residues of all commercial oils. In the hydrogenation process, hydrogen gas is forced into the oil at high pressures in the presence of a metal catalyst for a few hours. Hydrogenated vegetable fats contain altered molecules derived from fatty acids (trans fat) and many scientists believe these carry serious health risks.

    Discussion

    Is magnesium stearate safe? The information in the above paragraphs certainly flags up the need for caution in using magnesium stearate. To reiterate:

    •Toxicity; cotton crops are heavily sprayed and have the highest content of pesticide residues of all commercial oils.
    •Hydrogenation; hydrogenated vegetable fats contain altered molecules derived from fatty acids (trans fat) that have serious health risks.
    •Reduced bioavailability; decreased absorption of the product.

    Increasingly health conscious people are aware of the problems with pesticide toxicity and usage of hydrogenated oils, but few are aware of the issues involving supplement excipients such as magnesium stearate. A component of magnesium stearate is stearic acid. Research shows stearic acid suppresses the body's natural killer cells, a type of lymphocyte (a white blood cell) and a component of the innate immune system. It produces a reaction in the gut to form a film or lining that works as a barrier that stops or limits the absorption of nutrients.* Stearic acid may prevent absorption by individuals with compromised digestive systems. Magnesium stearate and stearic acid also present the problem that delivery of the active ingredient may be considerably further down the intestinal tract than the site originally intended. This may result in the nutrient being delivered away from its optimal absorption site. Not only can this impede absorption, in some cases it might be harmful to the liver.** The addition of palmitate or stearate to cultured cells led to activation of a death program with a morphology resembling that of apoptosis. Palmitates and stearates caused cardiac and other types of cells to undergo programmed cell death.***

    To achieve the correct flow properties magnesium stearate has to be thoroughly mixed with the active ingredients and in doing so magnesium stearate coats a good percentage of the molecules of the ingredients. This then requires digestive enzymes to first break down the magnesium stearate coating before being able to assimilate the nutrients, which has a negative impact for people suffering with digestion problems, the sick and elderly.

    Disintegration Time (DT)

    The standard disintegration time for immediate release oral dosage forms is generally within 15-30 minutes once in the stomach. One way to investigate the bioavailability of a supplement is to fill a glass with white vinegar (as this mimics stomach acid) and drop in a tablet or capsule. If the supplement does not dissolve or fully disintegrate within 30 minutes this will impact on the nutrients the human body is able to assimilate in the appropriate section of the intestines as intended.

    We manufacture our own supplements without magnesium stearate

    At Health Leads the quality of the product is paramount, not just the returns, so we will not use magnesium stearate or any other industry standard excipients that we believe to be detrimental. Many supplement manufacturers use magnesium stearate solely because it enables the faster production of supplements - saving a great deal of money - but at what cost to nutritive values.

    In choosing to manufacture our own additive free supplements, we go to great lengths to ensure the best available ingredients are used. There are a few nutritional supplements where it is not possible to fill capsules with only the active ingredient, in these cases we use organic rice flour. With our supplements we fill each capsule to the brim with the best ingredients, putting purity & quality first because we care about our customers.
    "Who looks outside, dreams; who looks inside, awakes."

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    Senior Member baby1's Avatar
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    Re: Potentially harmful filler in supps and meds

    I have to try to limit my intake of this. I have had to change a couple meds of mine to liquid and can use no supplements with this ingredient.

    have you ever taken a vitamin that has not digested at all and shows up in your poop? (sorry) One reason is because if your digestive system has a hard time breaking that sup down, because of the added filler, it will be of no benefit to you. I pay a higher price for supps without fillers but it is worth it
    "Who looks outside, dreams; who looks inside, awakes."

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    V.I.P. Ironguruera's Avatar
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    Re: Potentially harmful filler in supps and meds

    I pretty much assume anything a dr prescribes is poison, and there will shortly be a commercial with a class action lawsuit against the drug/drugs being prescribed.

    I trust the FDA and CDC......not at all!

    Only reason I even have insurance besides it being mandatory now is for my wife and kids. I go to the dr once every 3 yrs or less
    Blah blah blah Latina's ass...blah blah blah!

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    Senior Member baby1's Avatar
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    Re: Potentially harmful filler in supps and meds

    This is a filler also in most supplements and vitamins, not just meds. Magnesium stearate and stearic acid are both fillers and both I can not consume much of. If you check on your bottles, I bet they contain both if not one of these ingredients. Also found in soaps, lotions, shampoos etc. Hard to avoid completely but I do my best to limit it. Studies still claim this to be BS but I know for a fact that it bothers me .
    "Who looks outside, dreams; who looks inside, awakes."

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    Re: Potentially harmful filler in supps and meds

    Damn...always comin with some knowledge and info Baby1..thanks, gd to know and b on the lookout or at least on notice

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    Senior Member baby1's Avatar
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    Re: Potentially harmful filler in supps and meds

    ttt for good info today as today I am suffering from some side effects of this crap
    "Who looks outside, dreams; who looks inside, awakes."

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    Senior Member baby1's Avatar
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    Re: Potentially harmful filler in supps and meds

    just bumping this for some more good info on this. I am glad Analog Man posted info on this again. I think it is a culprit for some people and def for me. Check out articles from Dr Mercola, he writes good info on things like this
    "Who looks outside, dreams; who looks inside, awakes."

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    V.I.P. AnalogMan's Avatar
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    Re: Potentially harmful filler in supps and meds

    I never seen your thread Baby,(sorry) but should have known.. I could go for days on this, and your very correct.. It's in almost everything!!! Good for you. I knew you were very knowledgeable when we had the B12 chat. I love reading your threads. I hope I have , and can shed some light too,......AM
    Quote Originally Posted by baby1 View Post
    just bumping this for some more good info on this. I am glad Analog Man posted info on this again. I think it is a culprit for some people and def for me. Check out articles from Dr Mercola, he writes good info on things like this

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    Senior Member baby1's Avatar
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    Re: Potentially harmful filler in supps and meds

    Quote Originally Posted by AnalogMan View Post
    I never seen your thread Baby,(sorry) but should have known.. I could go for days on this, and your very correct.. It's in almost everything!!! Good for you. I knew you were very knowledgeable when we had the B12 chat. I love reading your threads. I hope I have , and can shed some light too,......AM

    Its an old thread but I am most glad to see more of us becoming aware of this. The more we all help and get words out , the better we can get. Usually, in real life, when I speak of things most think I am "out there",lol. To bad for them Keep on posting up these great things and a BIG 'thanks' to you, Analog Man, and everyone here. Everyone can learn something new everyday and none of us will ever know everything. I am fascinated with learning knew things..
    "Who looks outside, dreams; who looks inside, awakes."

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